Pagets Disease Research Paper

Osteopetrosis is a rare, genetic disease that causes extremely dense and brittle bones. This is because individuals affected with osteopetrosis do not have normal osteoclasts, which bones need to work correctly. Healthy bones require properly functioning osteoblasts and osteoclasts. Osteoblasts are responsible for making new bones and osteoclasts are bone cells that are responsible for bone resorption, which is the breaking down of bones and providing space for new bone marrow to grow. An individual with osteopetrosis has osteoclasts that do not function properly, therefore their bones are not healthy (Stocks, Wang, Thompson, Stocks, & Horwitz, 1998).

Osteogenesis Imperfecta, also known as Brittle Bone Disease, is a disease that effects bones and joints. Osteogenesis Imperfecta is a disease that effects child, and most often children are born with this disease. In some cases the disease may take a couple years to show symptoms, but more often than not the disease is recognized when the child is born. “Osteogenesis Imperfecta is caused by a defect in the gene which produces collagen 1, an important building block of bone” (Osteogenesis). The bones are very fragile, and often times break when touched or moved. The severity of the disease depends on which portion of the gene is affected. If a child is lucky, the disease may only affect a small portion of the gene, which would make the

They further stated that the main purpose of treatment is to provide relief of pain in the bone and to prevent further progression of the disease. The food and Drug administration has approved bisphosphonates and calcitonin medications that can stop or slow down the progression of Paget’s disease, and also help with the reduction of pain as well as other symptoms. The medications work by helping to stop or reduce the breakdown of old bones, which will then cause the excessive formation of new, weaker bones. It is important for people with Paget’s disease to discuss which medication is right for them with their

Osteoporosis is a condition that causes bone loss over time. This means that your bones become less dense. The open spaces inside your bones get bigger, and the walls between these spaces become thinner. Osteoporosis means "porous bones."

Staph infection comes in different types and may cause disease due to direct infection or production of toxins by the bacteria. Boils, impetigo, food poisoning, cellulitis, and toxic shock syndrome are all examples of diseases that can be caused by Staphylococcus [2]. MRSA is a form of bacterial infection that is resistant to numerous antibiotics including methicillin, amoxicillin, penicillin and oxacillin, thus making it challenging to treat the infection [3].

Hello everyone, I decided to research Paget's Disease for this week's unit 7 discussion. Paget's disease is a chronic bone disorder that typically results in enlarged deformed bones due to excessive breakdown, and formation of bone tissue that can cause bones to, weaken and may result in bone pain, arthritis deformities, or fractures. Paget's disease was named after a great English surgeon and pathologist Sir James Paget, who discovered this condition in 1877. Men and women are equally affected by this disease. Because Paget's disease can be passed on after age 40, brothers, sisters, and children of someone with this condition may want to have an alkaline phosphatase blood test every 2 or 3 years to screen for Paget's disease.

Osteomyelitis is a bone infection that is mostly caused by bacteria. The bacteria’s name is staphylococcus . Depending on how bad the bone is infected, plus the age of the person, different bacterias can cause you to have osteomyelitis. Having osteomyelitis as a child or teen, typically affects the long bones in the arms and legs.

because in children these bones have particularly extensive blood circulation, making them more susceptible to invasion by bacteria. Different patterns of blood circulation in adults make the long bones less well-served by the circulatory system. These bones are therefore unlikely to develop osteomyelitis in adult patients. Instead, the bones of the spine (vertebrae) receive a lot of blood flow. Therefore, osteomyelitis in adults is most likely to affect a vertebra. Drug addicts may have osteomyelitis in the pubic bone or clavicle. Spread from adjacent infected soft tissue; about 50% of all such cases are infected by Staphylococcus aureus. This often occurs in cases where recent surgery or injury has result in a soft tissue infection. The

This condition is more likely to occur in people between the ages of 15–40. This condition is also more common in Asia, Africa, the Middles East, and Central America.

Description of the disease – this refers to the cause and biological abnormality associated with the disease

Staphylococcus aureus is a specific type of “staph” bacteria that causes a range of infections, such as infection of an open

In 1877, an English surgeon and physiologist named Sir James Paget discovered Paget’s disease by the inflammatory of a bone also known as

Because there is often extensive osseous involvement and because individual areas progress at variable rates, Paget disease of differing phases may be seen in the same patient. The end result is a thickened, disorganized trabecular pattern of bone, referred to as a “mosaic” or “jigsaw” pattern .Cement lines along the coarsened and enlarged trabeculae are characteristically seen; these lines represent osseous resorption and bone formation . The trabecular areas of thickening usually lack the interconnection seen in normal bone and thus are weakened and often referred to as “pumice” bone

The prevalence of the disease occurs in diverse races, culture, and different age groups. Although, it is predominantly seen during old age, older teenagers and young adults also gets affected by it. It is a common problem with the female population against the male counterpart ("," 2014).

Paget’s disease, also known as Osteitis Deformans, this is a genetic disease that causes an abnormal processes of breakdown, reabsorption and rebuilding of osteocytes. This abnormal process effects focal bone remodeling and can lead to irregular structure and altered mechanical properties of the bones themselves. The bones become weak and results in pain, arthritis, bone deformities and fractures; however, it is still unclear of what the